*Clinical Data Manager Needed for an International Project*

Recruitment Notice
Job Description
Project: ELDORADO
Job Title: Clinical Data Manager
Professional Family: Clinical Research
Type of Employment Part Time
Duration: 12 months renewable with 03 months trial period
Location: ANRS- MIE / CREMER-IMPM, Yaoundé

I. Introduction
National Agency for Research on AIDS, Viral Hepatitis and Emerging Infectious Diseases (ANRS-MIE)
The ANRS | MIE Cameroon Site was created on January 25, 2005 following a
tripartite memorandum of understanding, renewed on December 16, 2021, between the ANRS, the Ministry of Public Health and the Ministry of
Scientific Research and Innovation. The Site is located within the Yaoundé Central Hospital and mobilizes
researchers from the North and the South, from all disciplines, and whatever their affiliations, around
scientific questions identified as priorities. The site’s mission is to lead, evaluate, coordinate
and monitor research projects on HIV/AIDS, viral hepatitis, STIs, tuberculosis and emerging infectious diseases sponsored or funded by the ANRS-MIE. It is
under the joint responsibility of a North coordinator and a South coordinator.
Center for Research on Emerging and Re-Emerging Diseases (CREMER)
The Center for Research on Emerging and Re-Emerging Diseases, officially created in 2009,
is one of the four Research Centers of the IMPM. Its missions focus on research on
emerging and re-emerging infectious diseases of immediate or potential importance in Public Health with
national or international scope. As part of its missions and under the authority of a CREMER Chief, the Center
develops and coordinates research activities on its own initiative or in collaboration with international partners, such as the IRD with which a collaboration agreement has existed for many
years. It is in this context of collaboration that one of the IRD’s most important partnership tools, the LMI (International Mixed Laboratory) has existed for almost 10 years between the TransVIHMI research unit based in Montpellier and CREMER.As part of the implementation of the ELDORADO project, it is necessary to recruit a 50% Data Manager who will be responsible for the daily management of the project data.

II. Job description
a) Background
Dolutegravir treatment has been associated with weight gain, particularly in women and
in subjects of sub-Saharan origin (NAMSAL and ADVANCE trials). The long-term deleterious impact
of increased weight gain on cardiovascular risk, hypertension and diabetes is a
worrying situation. Conversely, doravirine has been associated with moderate weight gain comparable to that
observed with other non-INSTI molecules. Efavirenz 400 mg is currently recommended by the WHO
as a possible alternative to dolutegravir, but very high rates of primary resistance mutations
in countries where nevirapine and efavirenz have been used for more than 20 years hamper its
widespread use. In a setting where there are no ongoing first-line studies comparing
doravirine to dolutegravir, a first-line study evaluating the non-inferiority of doravirine and its
better safety profile compared to dolutegravir in an ethnically diverse population is likely to have a major public health impact. Indeed, according to
WHO guidelines, dolutegravir remains the preferred first-line regimen for people
living with HIV starting ART. If non-inferiority is confirmed, doravirine could be
a preferred choice in certain populations to avoid adverse events related to
metabolic changes due to the INSTI-based regimen.
b) Primary objective of the study
To assess the non-inferiority of doravirine in combination with tenofovir and lamivudine, compared to dolutegravir in combination with tenofovir and lamivudine or emtricitabine, in terms of
virological efficacy at week 48, measured by the proportion of subjects achieving HIV-1 RNA < 50 copies/mL,
in HIV-1-infected, treatment-naïve subjects with a pre-treatment viral load (
HIV-1 RNA) ≥ 1,000 copies/mL.
c) Study location
The Cameroonian research team will be hosted at the ANRS Site and CREMER in Yaoundé. Patients will be recruited and followed at the Yaoundé Central Hospital.
d) Mission:
Reporting to the principal investigators, the Clinical Researcher Data Manager
‘s mission is to support the principal investigators to ensure a
data management in accordance with the trial protocol, local regulations and
Good Clinical Practice regulations. This includes, but is not limited to, the following activities:
• Develop and execute SOPs, guidelines and data standards to ensure
database quality control and data management compliance and stability.
• Develop, test and validate the data management system at the Cameroon site, to ensure
it reflects the requirements of the study data management procedures.
• Participate in study planning (including expertise in purchasing or verifying compliance of data management systems) to ensure timely start of
CRF installation, database and edit checks. • Train technicians in data entry using required and alternative data entry
methods . • Provide user support. • Direct data entry activities to ensure timely clinical project deliverables. • Manage and monitor the data entry flow in the platform and respond to queries and backup data as needed in a regular and timely manner. • Compile data to generate and develop summary reports and graphs as needed. • Use problem-solving techniques and judgment to apply to proper data management. • In collaboration with the Central Data Manager, participate in maintaining an adequate data management infrastructure that meets the trial requirements, including the verification of the security of the study data. • In collaboration with the research team, assess the study needs in the site on a weekly basis; • Participate in weekly, bi-weekly and monthly meetings. • Any other written or verbal instructions.

 III. Required Qualifications a) Skills • At least one year of experience in data management in clinical research preferred. • Strong skills in computer systems and database design environments , especially REDCAP (asset). • Ability to communicate in English and French, both orally and in writing. • Ability to work under pressure. • Application of Good Clinical Practices. • Application of the General Data Protection Regulation. b) Training

• Qualifications and training equivalent to at least an undergraduate degree in
Data Science/Informatics from a recognized training institution (BSc Data Science/Data Management/Health Informatics, Statistics).
• Current training in Good Clinical Practice.
c) Skills
• Meticulous, organized and autonomous person
• Maintains confidentiality of sensitive information and a strong professional ethic.
• Flexible, opinionated, calm and teachable.
• Ability to establish cooperative and constructive relationships with clients and colleagues.
• Ability to follow detailed written or verbal instructions.
• Adaptability and teamwork skills.
Applications consisting of a CV and a cover letter addressed to the
Scientific and Technical Co-coordinator of CREMER and copies of diplomas must be sent by email to the
following address cremerpresica@yahoo.com no later than September 10, 2025 at 3:00 p.m.
ANRS-MIE and CREMER, through their recruitment policies, promote professional equality between men and women. Only selected candidates will be contacted for an interview.